The Causal Role of Apolipoprotein B/A1 Ratio in Coronary Heart Disease and Ischemic Stroke: A Mendelian Randomization Study

Abstract excerpt

<h4>Background/Aims</h4> Although epidemiological analyses have suggested a link between a heightened ratio of apolipoprotein (Apo) B/A1 and atherosclerosis (ATS), the exact causative connection between ApoB/A1 and coronary heart disease (CHD) and ischemic stroke (IS) onset is ambiguous. Accordingly, our objective was to investigate the causal interaction between ApoB/A1 and both CHD and IS. <h4>Methods</h4> A Men...

Topics

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• Apolipoprotein A-I
• Apolipoprotein B-100
• Hypertension
• Mendelian Randomization Analysis
• Myocardial Infarction
• Peripheral Arterial Disease
• Risk Assessment
• Smoking

Identifiers and source

Literature Corpus work

681100de-8ca8-5d19-a4bd-4571c86ea0c9

DOI

10.1101/2025.06.11.25328879