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Article

Apolipoprotein A-I concentrations and risk of coronary artery disease: A Mendelian randomization study.

Atherosclerosis - 1 Apr 2020

Karjalainen Minna K, Holmes Michael V, Wang Qin, Anufrieva Olga, Kähönen Mika, Lehtimäki Terho, Havulinna Aki S, Kristiansson Kati, Salomaa Veikko, Perola Markus, Viikari Jorma S, Raitakari Olli T, Järvelin Marjo-Riitta, Ala-Korpela Mika, Kettunen Johannes

Abstract excerpt

BACKGROUND AND AIMS: Apolipoprotein A-I (apoA-I) infusions represent a potential novel therapeutic approach for the prevention of coronary artery disease (CAD). Although circulating apoA-I concentrations inversely associate with risk of CAD, the evidence base of this representing a causal relationship is lacking. The aim was to assess the causal role of apoA-I using human genetics. METHODS: We identified a...

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PMID: 32113648
DOI: 10.1016/j.atherosclerosis.2020.02.002

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