Apolipoprotein and peripheral artery disease: Mendelian randomization analysis.

Abstract excerpt

BackgroundThe prevalence of peripheral arterial disease (PAD) is on the rise globally, leading to adverse clinical outcomes. Our aim was to investigate the causal relationship between apolipoprotein and PAD, as well as the potential mediating role of smoking, diabetes, hypertension, myocardial infarction, and ischemic stroke.MethodsWe employed two-sample Mendelian randomization (TSMR) to assess the causal effect...

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• Apolipoprotein A-I
• Apolipoprotein B-100
• Hypertension
• Mendelian Randomization Analysis
• Myocardial Infarction