Article

Models of increased latent HIV reservoir turnover prior to cART initiation imply novel clearance strategies

2021-06-07

Abstract excerpt

CD4+ T cells with a naive or memory phenotype carrying a replication-competent HIV provirus are recognized as the major component of the persistent HIV reservoir. These cells only minimally express viral protein, reducing viral cytotoxicity effects and making them difficult targets for immune responses as well as every available antiretroviral drug. In patients on suppressive antiretroviral therapy, the half-life...

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Literature Corpus work: 67dcdf6a-add7-5c4c-9c5c-780081ca8ca7
DOI: 10.1101/2021.06.06.447292

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