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Cytotoxic T lymphocytes and viral turnover in HIV type 1 infection

24 Dec 1996

Abstract excerpt

To understand the role of the immune system in limiting HIV type 1 replication, it is critical to know to what extent the rapid turnover of productively infected cells is caused by viral cytopathicity or by immune-mediated lysis. We show that uncultured peripheral blood mononuclear cells of many patients contain cytotoxic T lymphocytes (CTL) that lyse target cells-at plausible peripheral blood mononuclear...

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PMID: 8986810
DOI: 10.1073/pnas.93.26.15323

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