Article

Identification of antibody-drug conjugate payloads which are substrates of ATP-binding cassette drug efflux transporters

2025-05-27

Abstract excerpt

<h4>Aim</h4> Antibody-drug conjugates (ADCs) feature an antibody recognizing a specific protein joined to a potent toxic payload. Numerous antibody-drug conjugates have received FDA approval; however, clinical resistance arises. Resistance mechanisms include decreased expression or mutation of the antibody target, impaired payload release, or increased expression of ATP-binding cassette (ABC) efflux transporters...

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Literature Corpus work: ec0f9b87-b721-5c39-bc7a-c7f716cbc3c0
DOI: 10.1101/2025.05.22.651305

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