Article

Antibody-drug conjugates with dual payloads for combating breast tumor heterogeneity and drug resistance

2020-12-21

Abstract excerpt

<h4>ABSTRACT</h4> Breast tumors generally consist of a diverse population of cells with varying gene expression profiles. Breast tumor heterogeneity is a major factor contributing to drug resistance, recurrence, and metastasis after chemotherapy. Antibody-drug conjugates (ADCs) are emerging chemotherapeutic agents with striking clinical success, including T-DM1 for HER2-positive breast cancer. However, these ADCs...

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Literature Corpus work: fd8b42ae-a81a-5bf2-9704-9c328e278b71
DOI: 10.1101/2020.12.18.423326

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