Predicting substrates for orphan Solute Carrier Proteins using multi- omics datasets

Abstract excerpt

<title>Abstract</title> <p>Solute carriers (SLC) are integral membrane proteins responsible for transporting a wide variety of metabolites, signaling molecules and drugs across cellular membranes. Despite key roles in metabolism, signaling and pharmacology, around one third of SLC proteins are ‘orphans’ whose substrates are unknown. Experimental determination of SLC substrates is technically challenging given the...

Topics

Open a Topic to create a Post that cites this publication.

• Amino Acid Enzymes and Metabolism
• Biomedical Research
• Drug Discovery
• Drug Transport and Resistance Mechanisms
• Gene Expression
• Genetic Predisposition to Disease
• Genome-Wide Association Study
• Membrane Transport Proteins

Identifiers and source

Literature Corpus work

67964d70-4761-5b62-9a6f-7409ec8ad3b2

DOI

10.21203/rs.3.rs-4713269/v1