Article

Plasma metabolomics of presymptomatic <i>PSEN1</i> -H163Y mutation carriers: A pilot study

2020-05-17

Abstract excerpt

<h4>Background and Objective</h4> PSEN1 -H163Y carriers, at the presymptomatic stage, have reduced 18 FDG-PET binding in the cerebrum of the brain [1]. This could imply dysfunctional energy metabolism in the brain. In this study, plasma of presymptomatic PSEN1 mutation carriers was analyzed to understand associated metabolic changes. <h4>Methods</h4> We analyzed plasma from non-carriers (NC, n=8) and presympt...

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Literature Corpus work: 678b9af5-472a-5645-8f7e-1994faacd897
DOI: 10.1101/2020.05.16.093559

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