Metabolomic and lipidomic signatures in autosomal dominant and late-onset Alzheimer's disease brains.

doi:10.1002/alz.12800

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Article

Metabolomic and lipidomic signatures in autosomal dominant and late-onset Alzheimer's disease brains.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 May 2023

Novotny Brenna C, Fernandez Maria Victoria, Wang Ciyang, Budde John P, Bergmann Kristy, Eteleeb Abdallah M, Bradley Joseph, Webster Carol, Ebl Curtis, Norton Joanne, Gentsch Jen, Dube Umber, Wang Fengxian, Morris John C, Bateman Randall J, Perrin Richard J, McDade Eric, Xiong Chengjie, Chhatwal Jasmeer, Goate Alison, Farlow Martin, Schofield Peter, Chui Helena, Karch Celeste M, Cruchaga Carlos, Benitez Bruno A, Harari Oscar

Abstract excerpt

INTRODUCTION: The identification of multiple genetic risk factors for Alzheimer's disease (AD) suggests that many pathways contribute to AD onset and progression. However, the metabolomic and lipidomic profiles in carriers of distinct genetic risk factors are not fully understood. The metabolome can provide a direct image of dysregulated pathways in the brain. METHODS: We interrogated metabolomic signatures in...

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PMID: 36251323
DOI: 10.1002/alz.12800
PMCID: PMC10106526

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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