Article

Polyol pathway dysregulation in CSF links glucose metabolism to tau pathology independently of amyloid and genetic predisposition

2026-05-08

Abstract excerpt

Dementia affects approximately 60 million people worldwide, yet molecular mechanisms linking early neuropathological changes to clinical progression remain poorly understood. We performed targeted and untargeted metabolomics in plasma and cerebrospinal fluid (CSF) from 166 memory clinic patients spanning no cognitive impairment, mild cognitive impairment due to Alzheimer’s disease (AD), AD dementia, and mixed AD–c...

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Literature Corpus work: eb242bf8-0f3a-5b80-90fa-c31f2fd0e939
DOI: 10.64898/2026.05.06.26352559

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