Article

Internalisation and biological activity of nucleic acids delivering cell-penetrating peptide nanoparticles is controlled by the biomolecular corona

2021-03-27

Abstract excerpt

Nucleic acid molecules can be transferred into cells to alter gene expression and, thus, alleviate certain pathological conditions. Cell-penetrating peptides (CPPs) are vectors that can be used for transfecting nucleic acids as well as many other compounds. CPPs associate nucleic acids non-covalently, forming stable nanoparticles and providing efficient transfection of cells in vitro . However, in vivo , expecte...

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Literature Corpus work: 678761dd-e865-533b-a754-479a5171548d
DOI: 10.1101/2021.03.26.437157

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