Article

Peptide additives reprogram the lipid nanoparticle corona and enhance gene delivery in a serum-free environment for lung epithelium

2026-07-13

Abstract excerpt

Lipid nanoparticles (LNPs) have become a clinical standard for systemically-administered nucleic acid drugs and vaccines, but the LNP pipeline for locally-delivered LNP therapies remains much less mature. Local delivery in lung represents a particularly compelling application space for DNA-LNP therapeutics, as local gene therapies could support sustained epithelial recovery and functional restoration in various lu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8d83fcdf-cacb-559f-b544-1f9fc9a7d7c5
DOI: 10.64898/2026.07.10.737795

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Peptide additives reprogram the lipid nanoparticle corona and enhance gene delivery in a serum-free environment for lung epitheliumDOI 10.64898/2026.07.10.737795Read

Lung surfactants as a component of lipid nanoparticles for pulmonary mRNA deliverySemantic proximity Read

Optimized inhaled LNP formulation for enhanced treatment of idiopathic pulmonary fibrosis via mRNA-mediated antibody therapySemantic proximity Read

Lipid nanoparticles for delivery of RNA therapeutics: Current status and the role of in vivo imagingSemantic proximity Read

Lung-selective mRNA delivery of synthetic lipid nanoparticles for the treatment of pulmonary lymphangioleiomyomatosisSemantic proximity Read

Polymer-lipid hybrid nanoparticle enhances mRNA delivery and T cell-mediated immunitySemantic proximity Read

Phase-separating enzyme-responsive condensates for inhalable delivery of biomacromoleculesSemantic proximity Read

Engineering of mRNA vaccine platform with reduced lipids and enhanced efficacySemantic proximity Read

Enhanced lung delivery of an immunostimulatory duplex RNA augments the antitumor activity by reshaping systemic cytokine pharmacodynamicsSemantic proximity Read

Reengineering mRNA lipid nanoparticles for systemic delivery to pancreasSemantic proximity Read

An inherent T cell-activating mRNA delivery platform for <i>in vivo</i> CAR T generationSemantic proximity Read

Pulmonary mRNA-LNP Vaccines for Rapid and Durable Protection Against Bacterial InfectionSemantic proximity Read

Lipid Nanoparticle Delivery Systems to Enable mRNA-Based TherapeuticsSemantic proximity Read