Article

Dual delivery of nucleic acids and PEGylated-bisphosphonates <i>via</i> calcium phosphate nanoparticles

2019-04-28

Abstract excerpt

Despite many years of research and a few success stories with gene therapeutics, efficient and safe DNA delivery remains a major bottleneck for the clinical translation of gene-based therapies. Gene transfection with calcium phosphate (CaP) nanoparticles brings the advantages of low toxicity, high DNA entrapment efficiency and good endosomal escape properties. The macroscale aggregation of CaP nanoparticles can be...

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Literature Corpus work: 48962b2c-aa0b-509a-9b18-3d636c136b44
DOI: 10.1101/621102

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