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Article

Let-7e sensitizes epithelial ovarian cancer to cisplatin through repressing DNA double strand break repair

4 Apr 2017

Abstract excerpt

BACKGROUND: Resistance to platinum-based chemotherapy remains a great challenge for ovarian cancer treatment. The human let-7 family contains 13 members located on nine different chromosomes, and most members have been implicated in the modulation of drug sensitivity in cancers. Our previous study showed that deregulation of let-7e in epithelial ovarian cancer (EOC) promoted the development of resistance to...

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PMID: 28376831
DOI: 10.1186/s13048-017-0321-8

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