Article
Kinesin family member 6 (kif6) is necessary for spine development in zebrafish.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Dec 2014
Buchan Jillian G, Gray Ryan S, Gansner John M, Alvarado David M, Burgert Lydia, Gitlin Jonathan D, Gurnett Christina A, Goldsmith Matthew I
Abstract excerpt
BACKGROUND: Idiopathic scoliosis is a form of spinal deformity that affects 2-3% of children and results in curvature of the spine without structural defects of the vertebral units. The pathogenesis of idiopathic scoliosis remains poorly understood, in part due to the lack of a relevant animal model. RESULTS: We performed a forward mutagenesis screen in zebrafish to identify new models for idiopathic scoliosis....
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