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Article

Zebrafish models of idiopathic scoliosis link cerebrospinal fluid flow defects to spine curvature.

Science (New York, N.Y.) - 10 Jun 2016

Grimes D T, Boswell C W, Morante N F C, Henkelman R M, Burdine R D, Ciruna B

Abstract excerpt

Idiopathic scoliosis (IS) affects 3% of children worldwide, yet the mechanisms underlying this spinal deformity remain unknown. Here we show that ptk7 mutant zebrafish, a faithful developmental model of IS, exhibit defects in ependymal cell cilia development and cerebrospinal fluid (CSF) flow. Transgenic reintroduction of Ptk7 in motile ciliated lineages prevents scoliosis in ptk7 mutants, and mutation of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27284198
DOI: 10.1126/science.aaf6419
PMCID: PMC5574193

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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