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Involvement of orexin nerves in early stage of Alzheimer’s disease model mice and preventive effect of orexin receptor antagonists

2025-01-29

Abstract excerpt

<h4>Background</h4> Mild cognitive impairment (MCI) is a condition between healthy cognition and dementia with a high probability of progression to Alzheimer’s disease (AD). Elevated levels of orexin (OX) have been reported in the cerebrospinal fluid of patients with MCI and AD. <h4>Objective</h4> To investigate the efficacy of dual OX receptor antagonists (suvorexant and lemborexant) in an early-stage AD mouse...

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Literature Corpus work
67323fa1-0826-5efe-bbd0-2533cc204971
DOI
10.1101/2025.01.28.635390
Open publication

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Involvement of orexin nerves in early stage of Alzheimer’s disease model mice and preventive effect of orexin receptor antagonistsDOI 10.1101/2025.01.28.635390
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