Article

A potent SARS-CoV-2 antibody neutralizes Omicron variant by disassembling the spike trimer

2022-03-22

Abstract excerpt

The continuous emergence of novel SARS-CoV-2 variants poses new challenges to the fight against the COVID-19 pandemic. The newly emerging Omicron strain caused serious immune escape and raised unprecedented concern all over the world. The development of antibody targeting conserved and universal epitope is urgently needed. A subset neutralizing antibody(nAbs) against COVID-19 from convalescent patients were isolat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1b3a84e4-0742-5121-85e9-bdbeba81a105
DOI: 10.1101/2022.03.21.485243

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A potent SARS-CoV-2 antibody neutralizes Omicron variant by disassembling the spike trimerDOI 10.1101/2022.03.21.485243Read

Structural Study of SARS-CoV-2 Antibodies Identifies a Broad-Spectrum Antibody That Neutralizes the Omicron Variant by Disassembling the Spike TrimerSemantic proximity Read

Molecular basis of broad neutralization against SARS-CoV-2 variants including Omicron by a human antibodySemantic proximity Read

Monoclonal Antibodies from COVID-19 Convalescent Patients Target Cryptic Epitopes for Universal SARS-CoV-2 NeutralizationSemantic proximity Read

Combating the SARS-CoV-2 Omicron variant with non-Omicron neutralizing antibodiesSemantic proximity Read

SARS-CoV-2 Omicron potently neutralized by a novel antibody with unique Spike binding propertiesSemantic proximity Read

Potent neutralization of SARS-CoV-2 variants of concern by an antibody with a unique genetic signature and structural mode of spike recognitionSemantic proximity Read

Comprehensive structural analysis reveals broad-spectrum neutralizing antibodies against SARS-CoV-2 Omicron variantsSemantic proximity Read

An unconventional VH1-2 antibody tolerates escape mutations and shows an antigenic hotspot on SARS-CoV-2 spike.Semantic proximity Read

Structural basis of a two-antibody cocktail exhibiting highly potent and broadly neutralizing activities against SARS-CoV-2 variants including diverse Omicron sublineagesSemantic proximity Read

Combating the SARS-CoV-2 Omicron (BA.1) and BA.2 with potent bispecific antibodies engineered from non-Omicron neutralizing antibodiesSemantic proximity Read

A Bispecific Antibody Targeting RBD and S2 Potently Neutralizes SARS-CoV-2 Omicron and Other Variants of ConcernSemantic proximity Read

Function and Cryo-EM structures of broadly potent bispecific antibodies against multiple SARS-CoV-2 Omicron sublineagesSemantic proximity Read