Article

Myonuclear alterations associated with exercise are independent of age in humans

2022-09-21

Abstract excerpt

Age-related decline in skeletal muscle structure and function can be mitigated by regular exercise. However, the precise mechanisms that govern this are not fully understood. The nucleus plays an active role in translating forces into biochemical signals (mechanotransduction), with nuclear lamina protein Lamin A regulating nuclear shape, nuclear mechanics, and ultimately gene expression. Defective Lamin A expressi...

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Literature Corpus work: 6719d04d-61da-5e9e-a7a7-96ec1117dc24
DOI: 10.1101/2022.09.20.506578

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