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Multi-Site Investigation of Gut Microbiota in CDKL5 Deficiency Disorder Mouse Models: Targeting Dysbiosis to Improve Neurological Outcomes

2024-03-19

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Cyclin-Dependent Kinase-Like 5 (CDKL5) deficiency disorder (CDD) is a rare X-linked developmental encephalopathy caused by pathogenic variants of the CDKL5 gene. In addition to a diverse range of neurological symptoms, CDD patients frequently manifest gastrointestinal (GI) issues and subclinical immune dysregulation. This comorbidity suggests a potential association with the...

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Literature Corpus work
d5025df4-17f2-5f24-a0b5-70bd832c6f15
DOI
10.1101/2024.03.19.581742
Open publication

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