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Article

Prenatal hypoxia may aggravate the cognitive impairment and Alzheimer's disease neuropathology in APPSwe/PS1A246E transgenic mice.

Neurobiology of aging - 1 Mar 2013

Zhang Xin, Li Lixi, Zhang Xiaojie, Xie Wenjie, Li Liang, Yang Dehua, Heng Xin, Du Yunlan, Doody Rachelle S, Le Weidong

Abstract excerpt

Most cases of Alzheimer's disease (AD) arise through interactions between genetic and environmental factors. It is believed that hypoxia is an important environmental factor influencing the development of AD. Our group has previously demonstrated that hypoxia increased β-amyloid (Aβ) generation in aged AD mice. Here, we further investigate the pathological role of prenatal hypoxia in AD. We exposed the pregnant...

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Source

Identifiers

PMID: 22795785
DOI: 10.1016/j.neurobiolaging.2012.06.012

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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