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Exercise during pregnancy mitigates Alzheimer‐like pathology in mouse offspring

24 Sept 2011

Abstract excerpt

Physical activity protects brain function in healthy individuals and those with Alzheimer's disease (AD). Evidence for beneficial effects of parental exercise on the health status of their progeny is sparse and limited to nondiseased individuals. Here, we questioned whether maternal running interferes with offspring's AD-like pathology and sought to decipher the underlying mechanisms in TgCRND8 mice. Maternal...

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Identifiers

PMID: 21948247
DOI: 10.1096/fj.11-193193

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