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Article

Long-term social isolation exacerbates the impairment of spatial working memory in APP/PS1 transgenic mice.

Brain research - 31 Jan 2011

Huang Hei-Jen, Liang Keng-Chen, Ke Hsing-Chieh, Chang Yen-Yu, Hsieh-Li Hsiu Mei

Abstract excerpt

The interaction between gene and environment is known to play a major role in the etiology of several neuropsychiatric disorders, including Alzheimer's disease (AD). The present study evaluated whether environmental manipulations such as social isolation may affect the genetic predisposition to accelerate the onset of AD-related symptoms in an adult APP/PS1 double mutant transgenic mouse model. Transgenic and...

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Brain Chemistry
Memory Disorders
Mice, Inbred C3H
Neurotransmitter Agents
Presenilin-1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Receptors, N-Methyl-D-Aspartate

Social Isolation

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Identifiers

PMID: 21114967
DOI: 10.1016/j.brainres.2010.11.043

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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