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Article

A single proteolytic cleavage within the lower hinge of trastuzumab reduces immune effector function and in vivo efficacy

8 Aug 2012

Abstract excerpt

INTRODUCTION: Recent studies reported that human IgG antibodies are susceptible to specific proteolytic cleavage in their lower hinge region, and the hinge cleavage results in a loss of Fc-mediated effector functions. Trastuzumab is a humanized IgG1 therapeutic monoclonal antibody for the treatment of HER2-overexpressing breast cancers, and its mechanisms of action consist of inhibition of HER2 signaling and...

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PMID: 22873525
DOI: 10.1186/bcr3240

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