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Motive and opportunity: <i>MYC</i> rearrangements in high-grade B-cell lymphoma with <i>MYC</i> and <i>BCL2</i> rearrangements (an LLMPP study)

3 May 2024

Abstract excerpt

ABSTRACT: Rearrangements that place the oncogenes MYC, BCL2, or BCL6 adjacent to superenhancers are common in mature B-cell lymphomas. Lymphomas with diffuse large B-cell lymphoma (DLBCL) or high-grade morphology with both MYC and BCL2 rearrangements are classified as high-grade B-cell lymphoma with MYC and BCL2 rearrangements ("double hit"; HGBCL-DH-BCL2) and are associated with aggressive disease and poor...

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Identifiers

PMID: 38701426
DOI: 10.1182/blood.2024024251

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