Multi-ancestry gene expression models amplify transcriptome-wide association study discovery and validation.

Abstract excerpt

Our understanding of the influence of ancestral background on genetically determined expression remains limited, especially when gene expression models are applied to studies from different or multiple populations. We perform transcriptome-wide association studies of 6 psychiatric conditions, leveraging gene expression models trained in cohorts with different proportions of African, European, and Indigenous...

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• Black People
• Gene Expression Profiling
• Genome-Wide Association Study
• Mental Disorders
• Models, Genetic