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Article

Molecular Alterations Associated with DNA Repair in Pancreatic Adenocarcinoma Are Associated with Sites of Recurrence.

Journal of gastrointestinal cancer - 1 Jun 2019

Ferguson Margaret D, Dong Lei, Wan Jim, Deneve Jeremiah L, Dickson Paxton V, Behrman Stephen W, Shibata David, Martin Mike G, Glazer Evan S

Abstract excerpt

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest malignancies with a rising incidence. Mutational analysis of PDAC has provided valuable information but has not yet dramatically changed the therapeutic landscape due to the number of variations detected in any one individual. The pattern of molecular alterations-gene mutations, variations in copy number, and changes in gene...

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Identifiers

PMID: 29427136
DOI: 10.1007/s12029-018-0073-8

Genes

KRAS
ERCC1
PTEN

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