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Article

Computational studies of tryptophanyl-tRNA synthetase: activation of ATP by induced-fit.

Journal of molecular biology - 6 Oct 2006

Kapustina Maryna, Carter Charles W

Abstract excerpt

Catalysis of amino acid activation by Bacillus stearothermophilus tryptophanyl-tRNA synthetase involves three allosteric states: (1) Open; (2) closed pre-transition state (PreTS); and (3) closed products (Product). The interconversions of these states entail significant domain motions driven by ligand binding. We explore the application of molecular dynamics simulations to investigate ligand-linked conformational...

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Identifiers

PMID: 16949606
DOI: 10.1016/j.jmb.2006.06.078

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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