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Article

Nucleotide triphosphate promiscuity in Mycobacterium tuberculosis dethiobiotin synthetase.

Tuberculosis (Edinburgh, Scotland) - 1 May 2015

Salaemae Wanisa, Yap Min Y, Wegener Kate L, Booker Grant W, Wilce Matthew C J, Polyak Steven W

Abstract excerpt

Dethiobiotin synthetase (DTBS) plays a crucial role in biotin biosynthesis in microorganisms, fungi, and plants. Due to its importance in bacterial pathogenesis, and the absence of a human homologue, DTBS is a promising target for the development of new antibacterials desperately needed to combat antibiotic resistance. Here we report the first X-ray structure of DTBS from Mycobacterium tuberculosis (MtDTBS) bound...

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Identifiers

PMID: 25801336
DOI: 10.1016/j.tube.2015.02.046

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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