Article

Read depth correction for somatic mutations

2022-02-19

Abstract excerpt

<h4>ABSTRACT</h4> The ability to accurately detect mutations is a function of read depth and variant allele frequency (VAF). While the read depth distribution of a sample is observable, the true VAF distribution of all mutations in a sample is uncertain when there is low coverage depth. We propose to estimate the VAF distributions that would be observed with high-depth sequencing for samples with low sequencing d...

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Literature Corpus work: 668b9b9d-3ccc-55eb-ba56-833400f866c7
DOI: 10.1101/2022.02.16.480761

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