Article

Detection and benchmarking of somatic mutations in cancer genomes using RNA-seq data

2018-01-17

Abstract excerpt

<h4>ABSTRACT</h4> To detect functional somatic mutations in tumor samples, whole-exome sequencing (WES) is often used for its reliability and relative low cost. RNA-seq, while generally used to measure gene expression, can potentially also be used for identification of somatic mutations. However there has been little systematic evaluation of the utility of RNA-seq for identifying somatic mutations. Here, we devel...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0eea7c33-5fa1-5ee7-9ca8-ac26a6547d0f
DOI: 10.1101/249219

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Detection and benchmarking of somatic mutations in cancer genomes using RNA-seq dataDOI 10.1101/249219Read

Pan-cancer discovery of somatic mutations from RNA sequencing data.Semantic proximity Read

Using RNA-Seq Data for the Detection of a Panel of Clinically Relevant Mutations.Semantic proximity Read

Identification of cancer drivers from tumor-only RNA-seq with RNA-VACAYSemantic proximity Read

Whole genome sequencing analysis for cancer genomics and precision medicine.Semantic proximity Read

Identifying cancer mutation targets across thousands of samples: MuteProc, a high throughput mutation analysis pipeline.Semantic proximity Read

Integrating WES and RNA-Seq Data For Short Variant DiscoverySemantic proximity Read

Systematic discovery of gene fusions in pediatric cancer by integrating RNA-seq and WGSSemantic proximity Read

Accurate detection of somatic single-nucleotide variants from bulk RNA-seq data using RNA-MosaicHunter.Semantic proximity Read

COSMIC: a curated database of somatic variants and clinical data for cancer.Semantic proximity Read

Genomic basis for RNA alterations revealed by whole-genome analyses of 27 cancer typesSemantic proximity Read

Optimized pipeline of MuTect and GATK tools to improve the detection of somatic single nucleotide polymorphisms in whole-exome sequencing data.Semantic proximity Read

SomaMutDB 2.0: A comprehensive database for exploring somatic mutations and their functional impact in normal human tissuesSemantic proximity Read