Article

Bias and Inconsistency in the Estimation of Tumour Mutation Burden

2022-05-25

Abstract excerpt

<h4>Background: </h4> Tumour mutation burden (TMB), defined as the number of somatic mutations per megabase within the sequenced region in the tumour sample, has been used as a biomarker for predicting response to immune therapy. Several studies have been conducted to assess the utility of TMB for various cancer types; however, methods to measure TMB have not been adequately evaluated. In this study, we identified...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c9af6ef7-cdec-5aee-8682-1c12842a65d1
DOI: 10.21203/rs.3.rs-1637632/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Bias and Inconsistency in the Estimation of Tumour Mutation BurdenDOI 10.21203/rs.3.rs-1637632/v1Read

Bias and inconsistency in the estimation of tumour mutation burden.Semantic proximity Read

Systematic assessment and optimizing algorithm of tumor mutational burden calculation and their implications in clinical decision-makingSemantic proximity Read

ecTMB: a robust method to estimate and classify tumor mutational burdenSemantic proximity Read

Influence of low tumor content on tumor mutational burden estimation by whole-exome sequencing and targeted panel sequencing.Semantic proximity Read

Methods of measurement for tumor mutational burden in tumor tissueSemantic proximity Read

ecTMB: a robust method to estimate and classify tumor mutational burden.Semantic proximity Read

Estimating tumor mutational burden across multiple cancer types using whole-exome sequencingSemantic proximity Read

Benchmarking bioinformatics approaches for tumour mutational burden evaluation from a large cancer panel against whole-exome sequencing.Semantic proximity Read

Tumour mutational burden: clinical utility, challenges and emerging improvements.Semantic proximity Read

Tumor Mutational Burden From Tumor-Only Sequencing Compared With Germline Subtraction From Paired Tumor and Normal Specimens.Semantic proximity Read

Read depth correction for somatic mutationsSemantic proximity Read

Aligning tumor mutational burden (TMB) quantification across diagnostic platforms: phase II of the Friends of Cancer Research TMB Harmonization Project.Semantic proximity Read