Article

Updates to the reference genome alter the detection and direction of genes differentially expressed in Alzheimer’s disease

2026-08-19

Abstract excerpt

Alzheimer’s Disease gene expression studies often rely on the reproducibility of known disease associations to build confidence in novel discoveries. This approach assumes that true biological variation associated with Alzheimer’s Disease is robust to a range of technical and biological confounders that likely differ across experiments. Here, we systematically assess the impact of an important yet frequently overl...

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Literature Corpus work: 65f4767f-bc40-5864-a14d-cee17d3e5041
DOI: 10.1186/s13059-026-04213-9

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