Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting the actin nucleation promoting factor WASp provides a therapeutic approach for hematopoietic malignancies

22 Sept 2021

Abstract excerpt

Cancer cells depend on actin cytoskeleton rearrangement to carry out hallmark malignant functions including activation, proliferation, migration and invasiveness. Wiskott-Aldrich Syndrome protein (WASp) is an actin nucleation-promoting factor and is a key regulator of actin polymerization in hematopoietic cells. The involvement of WASp in malignancies is incompletely understood. Since WASp is exclusively...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to Cell Adhesion Molecules Research
Share to Cellular Mechanics and Interactions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34552085
DOI: 10.1038/s41467-021-25842-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting the actin nucleation promoting factor WASp provides a therapeutic approach for hematopoietic malignanciesPMID 34552085Read ↗

A first-in-class Wiskott-Aldrich syndrome protein (WASp) activator with anti-tumor activity in hematological cancersSemantic proximity Read ↗

The Wiskott-Aldrich syndrome protein (WASP): roles in signaling and cytoskeletal organization.Semantic proximity Read ↗

Mechanisms of WASp-mediated hematologic and immunologic disease.Semantic proximity Read ↗

Wiskott-Aldrich syndrome: a comprehensive review.Semantic proximity Read ↗

Cellular functions of WASP family proteins at a glanceSemantic proximity Read ↗

The Wiskott-Aldrich syndrome.Semantic proximity Read ↗

Clinical spectrum, pathophysiology and treatment of the Wiskott–Aldrich syndromeSemantic proximity Read ↗

Recent advances in understanding the pathophysiology of Wiskott-Aldrich syndrome.Semantic proximity Read ↗

A systematic approach to understanding how patient variants affect the activity of Wiskott-Aldrich syndrome proteinSemantic proximity Read ↗

Understanding immunoactinopathies: A decade of research on WAS gene defects.Semantic proximity Read ↗

WASP and WAVE family proteins: Friends or foes in cancer invasion?Semantic proximity Read ↗

The Actin Regulators Involved in the Function and Related Diseases of LymphocytesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.