Article

Control of CDH1 and IDH1mut glioblastoma cell cycle by D-2- hydroxyglutarate

2024-04-19

Abstract excerpt

Glioblastoma (GBM) is a prevalent and lethal primary brain tumor. Patients with the IDH1 R132H (isocitrate dehydrogenase 1) mutation exhibit extended survival and aneuploidy, yet the underlying mechanisms are unclear. Here, we reveal that the accumulation of D-2-hydroxyglutarate (2-HG) produced by IDH1 R132H mutation induces the degradation of Fizzy-related protein1(FZR1 or CDH1) by inhibiting prolyl hydroxylase E...

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Literature Corpus work: 65d30715-3069-5d9d-b3b1-0d03a71565be
DOI: 10.21203/rs.3.rs-4240423/v1

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