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Article

IDH1 mutations inhibit multiple α-ketoglutarate-dependent dioxygenase activities in astroglioma.

Journal of neuro-oncology - 1 Sept 2012

Liu Ying, Jiang Wenqing, Liu Jing, Zhao Shimin, Xiong Ji, Mao Ying, Wang Yin

Abstract excerpt

The mechanism of tumorigenesis associated with nicotinamide adenine dinucleotide phosphate (NADP(+))-dependent isocitrate dehydrogenase 1 (IDH1) mutations in gliomas is not fully understood. Loss of catalytic activity leading to a decrease in α-ketoglutarate (αKG) and gain of novel catalytic activity leading to production of D: -2-hydroxylglutarate (D: -2-HG) are both found in IDH1-mutated glioma cells. Both the...

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Source

Identifiers

PMID: 22772731
DOI: 10.1007/s11060-012-0914-4

Genes

IDH1
IDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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