Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Oncometabolite D-2-hydroxyglutarate regulates actin dynamics and nuclear homeostasis in IDH1-mutant glioma.

Cellular signalling - 1 Jul 2026

Lathoria Kirti, Umdor Sonia B, Patrick Shruti, Gowda Pruthvi, Singh Jyotsna, Joshi Shanker Datt, Suri Vaishali, Sen Ellora

Abstract excerpt

In gliomas harboring IDH1 mutations, accumulation of the oncometabolite D-2-hydroxyglutarate (D-2-HG) drives epigenetic dysregulation and altered signaling pathways. Though dysregulated actin cytoskeletal architecture is a hallmark of glioblastoma, the influence of glioma-associated oncometabolites on actin dynamics remains poorly understood. Genome-wide DNA methylation analysis of patient tumor biopsies...

Topics

Join the communities discussing this publication.

Actins
Brain Neoplasms
Glioma
Glutarates
Histones

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Isocitrate Dehydrogenase

Source

Identifiers

PMID: 41748045
DOI: 10.1016/j.cellsig.2026.112449

Genes

IDH1
TERT
CDC42
CFL1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Oncometabolite D-2-hydroxyglutarate regulates actin dynamics and nuclear homeostasis in IDH1-mutant glioma.PMID 41748045Read ↗

Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate.Semantic proximity Read ↗

Inhibition of 2-hydroxyglutarate elicits metabolic reprogramming and mutant IDH1 glioma immunity in miceSemantic proximity Read ↗

D-2-Hydroxyglutarate in Glioma Biology.Semantic proximity Read ↗

The Emerging Role of D-2-Hydroxyglutarate as an Oncometabolite in Hematolymphoid and Central Nervous System NeoplasmsSemantic proximity Read ↗

Oncogenic Activities of IDH1/2 Mutations: From Epigenetics to Cellular Signaling.Semantic proximity Read ↗

Beyond Brooding on Oncometabolic Havoc in IDH-Mutant Gliomas and AML: Current and Future Therapeutic StrategiesSemantic proximity Read ↗

The IDH1 Mutation-Induced Oncometabolite, 2-Hydroxyglutarate, May Affect DNA Methylation and Expression of PD-L1 in GliomasSemantic proximity Read ↗

DNA damage in IDH-mutant gliomas: mechanisms and clinical implications.Semantic proximity Read ↗

Metabolic modulation of epigenetics in gliomas.Semantic proximity Read ↗

Inhibition of 2-Hydroxyglutrate Elicits Metabolic-reprograming and Mutant IDH1 Glioma ImmunitySemantic proximity Read ↗

(R)-2-Hydroxyglutarate Inhibits KDM5 Histone Lysine Demethylases to Drive Transformation in IDH-Mutant Cancers.Semantic proximity Read ↗

Integrated transcriptomic analysis reveals KRAS-associated gene activation and epigenetic regulation in mutant IDH1 glioma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.