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Article

Oncometabolite D-2-hydroxyglutarate regulates actin dynamics and nuclear homeostasis in IDH1-mutant glioma.

Cellular signalling - 1 Jul 2026

Lathoria Kirti, Umdor Sonia B, Patrick Shruti, Gowda Pruthvi, Singh Jyotsna, Joshi Shanker Datt, Suri Vaishali, Sen Ellora

Abstract excerpt

In gliomas harboring IDH1 mutations, accumulation of the oncometabolite D-2-hydroxyglutarate (D-2-HG) drives epigenetic dysregulation and altered signaling pathways. Though dysregulated actin cytoskeletal architecture is a hallmark of glioblastoma, the influence of glioma-associated oncometabolites on actin dynamics remains poorly understood. Genome-wide DNA methylation analysis of patient tumor biopsies...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41748045
DOI: 10.1016/j.cellsig.2026.112449

Genes

IDH1
TERT
CDC42
CFL1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 21 Oct 2026.

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