Article

Retromer Opposes Opioid-Induced Downregulation of the Mu Opioid Receptor

2024-12-02

Abstract excerpt

The mu opioid receptor (MOR) is protected from opioid-induced trafficking to lysosomes and proteolytic downregulation by its ability to access the endosomal recycling pathway through its C-terminal recycling motif, LENL. MOR sorting towards the lysosome results in downregulation of opioid signaling while recycling of MOR to the plasma membrane preserves signaling function. However, the mechanisms by which LENL pro...

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Literature Corpus work: 65b65040-b3f8-5628-a9e6-a2cb30bfdf8e
DOI: 10.1101/2024.12.02.626482

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