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Fitness barriers to spread of colistin resistance overcome by first establishing niche in patients with enhanced colistin exposure

2021-06-13

Abstract excerpt

There is an urgent need to improve our understanding of how new antibiotic resistant organisms emerge and spread. A high-priority resistance threat is the ST258 lineage of carbapenem-resistant Klebsiella pneumoniae . Here, we studied resistance to the last-line drug colistin among ST258 by tracking its evolution across 21 U.S. hospitals over the course of a year. Phylogenetic analysis supported a significant fitne...

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Literature Corpus work
657dcf21-b9d8-5586-95a5-13b9e3337a8c
DOI
10.1101/2021.06.11.21258758
Open publication

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Fitness barriers to spread of colistin resistance overcome by first establishing niche in patients with enhanced colistin exposureDOI 10.1101/2021.06.11.21258758
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