Comparative in vivo evaluation of colistin resistance determinants in Escherichia coli clone ST131.

doi:10.1016/j.ebiom.2026.106423

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Article

Comparative in vivo evaluation of colistin resistance determinants in Escherichia coli clone ST131.

EBioMedicine - 1 Sept 2026

Sato Toyotaka, Yamamoto Soh, Toyting-Hiraishi Jirachaya, Tohyama Mana, Usui Masaru, Inoue Hiharu, Ogasawara Noriko, Ikenaka Yoshinori, Hayashi Wataru, Kosako Hidetaka, Suzuki Masato, Nagano Noriyuki, Wada Takayuki, Nakajima Chie, Suzuki Yasuhiko, Horiuchi Motohiro, Takahashi Satoshi, Yokota Shin-Ichi, Tamura Yutaka

Abstract excerpt

BACKGROUND: Colistin is a last-resort antimicrobial for multidrug-resistant (MDR) Gram-negative infections. Health risks associated with colistin resistance are commonly inferred from resistance phenotypes, despite limited in vivo evidence linking resistance determinants to pathogenic outcomes. Whether distinct colistin resistance determinants confer differential clinical risks remains unknown. METHODS: Using the...

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Topics

Colistin
Animals
Escherichia coli
Drug Resistance, Bacterial
Anti-Bacterial Agents

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Female

Escherichia coli Infections

Mice

Virulence

Microbial Sensitivity Tests

Escherichia coli Proteins

Mutation

Plasmids

Virulence Factors

Disease Models, Animal

Source

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Identifiers

PMID: 42556136
DOI: 10.1016/j.ebiom.2026.106423
PMCID: PMC13470554

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