Article
Multi-institute analysis of carbapenem resistance reveals remarkable diversity, unexplained mechanisms, and limited clonal outbreaks.
Proceedings of the National Academy of Sciences of the United States of America - 31 Jan 2017
Cerqueira Gustavo C, Earl Ashlee M, Ernst Christoph M, Grad Yonatan H, Dekker John P, Feldgarden Michael, Chapman Sinéad B, Reis-Cunha João L, Shea Terrance P, Young Sarah, Zeng Qiandong, Delaney Mary L, Kim Diane, Peterson Ellena M, O'Brien Thomas F, Ferraro Mary Jane, Hooper David C, Huang Susan S, Kirby James E, Onderdonk Andrew B, Birren Bruce W, Hung Deborah T, Cosimi Lisa A, Wortman Jennifer R, Murphy Cheryl I, Hanage William P
Abstract excerpt
Carbapenem-resistant Enterobacteriaceae (CRE) are among the most severe threats to the antibiotic era. Multiple different species can exhibit resistance due to many different mechanisms, and many different mobile elements are capable of transferring resistance between lineages. We prospectively sampled CRE from hospitalized patients from three Boston-area hospitals, together with a collection of CRE from a single...
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