Article

Tirzepatide reduces diet-induced senescence and NETosis-mediated liver fibrosis in mice

2025-05-29

Abstract excerpt

Lipofuscin, a protein-lipid complex that progressively accumulates in senescent cells, was commonly observed in the liver biopsies from patients with liver fibrosis or cirrhosis regardless of the etiological insults. However, whether and how lipofuscin contributes to the development of liver fibrosis remains unknown. Using a mouse model of liver fibrosis induced by choline-deficient L-amino acid-defined high-fat d...

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Identifiers and source

Literature Corpus work: 656ba493-2585-5217-9ddf-71c3b49dcf73
DOI: 10.1101/2025.05.27.656284

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