Article
Complement gene variants in relation to autoantibodies to beta cell specific antigens and type 1 diabetes in the TEDDY Study.
Scientific reports - 16 Jun 2016
Törn Carina, Liu Xiang, Hagopian William, Lernmark Åke, Simell Olli, Rewers Marian, Ziegler Anette-G, Schatz Desmond, Akolkar Beena, Onengut-Gumuscu Suna, Chen Wei-Min, Toppari Jorma, Mykkänen Juha, Ilonen Jorma, Rich Stephen S, She Jin-Xiong, Sharma Ashok, Steck Andrea, Krischer Jeffrey
Abstract excerpt
A total of 15 SNPs within complement genes and present on the ImmunoChip were analyzed in The Environmental Determinants of Diabetes in the Young (TEDDY) study. A total of 5474 subjects were followed from three months of age until islet autoimmunity (IA: n = 413) and the subsequent onset of type 1 diabetes (n = 115) for a median of 73 months (IQR 54-91). Three SNPs within ITGAM were nominally associated...
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