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Article

Genetic mapping of complement system proteins for islet autoimmunity in children with high risk of T1D.

Communications biology - 26 Sept 2025

Hu Xiaowei, Webb-Robertson Bobbie-Jo M, Parikh Hemang M, Nakayasu Ernesto S, Onengut-Gumuscu Suna, Chen Wei-Min, Frazer-Abel Ashley, Metz Thomas O, Rich Stephen S, Rewers Marian J, Manichaikul Ani

Abstract excerpt

Recent studies have reported the involvement of complement system proteins in the initiation and progression of islet autoimmunity (IA) in the study of Type 1 diabetes (T1D). However, the genetic factors of complement system proteins at the time of triggering of IA are unknown. Through complement system protein quantitative trait locus (pQTL) mapping discovery analysis of 170 participants from the Diabetes...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Chromosome Mapping

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Source

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Identifiers

PMID: 41006577
DOI: 10.1038/s42003-025-08739-9
PMCID: PMC12475137

Genes

C4A
CFB
C8A
C8B
MBL2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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