Article

ABHD6 inhibition rescues a sex-dependent deficit in motor coordination in the HdhQ200/200 mouse model of Huntington’s disease

2021-02-24

Abstract excerpt

Huntington’s Disease is associated with motor behavior deficits that current therapeutics do not alleviate. This pilot study tested if pharmacological inhibition of a/b-hydrolase domain containing 6 (ABHD6), a multifunctional enzyme expressed in the striatum, rescues behavioral deficits in HdhQ200/200 mice. Previous work has shown that this model exhibits a reduction in spontaneous locomotion and motor coordinatio...

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Literature Corpus work: 652f2e2a-3319-5225-b790-e297c6020997
DOI: 10.21203/rs.3.rs-230223/v1

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