Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Female sex mitigates motor and behavioural phenotypes in TDP-43Q331K knock-in mice.

Scientific reports - 5 Nov 2020

Watkins Jodie, Ghosh Anshua, Keerie Amy F A, Alix James J P, Mead Richard J, Sreedharan Jemeen

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are overlapping neurodegenerative disorders. ALS is more commonly seen in men than women and the same may be the case for FTD. Preclinical models demonstrating sex-specific vulnerability may help to understand female resistance to ALS-FTD and thereby identify routes to therapy. We previously characterised a TDP-43Q331K knock-in mouse, which...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to Behavior, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Models, Animal

Share to Eating

Share to Motor Activity

Share to Sex Factors

Share to Weight Gain

Source

Open in PubMed Open full text

Identifiers

PMID: 33154447
DOI: 10.1038/s41598-020-76070-w
PMCID: PMC7645778

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Female sex mitigates motor and behavioural phenotypes in TDP-43Q331K knock-in mice.PMID 33154447Read ↗

Multi-modal comparative phenotyping of knock-in mouse models of frontotemporal dementia/amyotrophic lateral sclerosis.Semantic proximity Read ↗

Delineating sex-dependent and anatomic decline of motor functions in the SOD1G93A mouse model of amyotrophic lateral sclerosisSemantic proximity Read ↗

Extensive phenotypic characterisation of a human TDP-43Q331K transgenic mouse model of amyotrophic lateral sclerosis (ALS)Semantic proximity Read ↗

Sex-Specific, Intermediate Behavioral Phenotypes in Heterozygous Dopamine Transporter Mutant DAT T356M Mice.Semantic proximity Read ↗

Sex-specific hypothalamic axis disruption in the rNLS8 mouse model of amyotrophic lateral sclerosis (ALS)Semantic proximity Read ↗

Phenotypic characterisation of the Mucopolysaccharidosis Type I (MPSI) Idua-W392X mouse model reveals increased anxiety-related traits in female mice.Semantic proximity Read ↗

Loss of murine TDP-43 disrupts motor function and plays an essential role in embryogenesis.Semantic proximity Read ↗

Mitochondrial dysfunction and decrease in body weight of a transgenic knock-in mouse model for TDP-43.Semantic proximity Read ↗

Age- and Sex-Dependent Behavioral and Neurochemical Alterations in hLRRK2-G2019S BAC Mice.Semantic proximity Read ↗

Coexistence of perseveration and apathy in the TDP-43Q331K knock-in mouse model of ALS-FTD.Semantic proximity Read ↗

PGC-1α is a male-specific disease modifier of human and experimental amyotrophic lateral sclerosis.Semantic proximity Read ↗

Early Cognitive/Social Deficits and Late Motor Phenotype in Conditional Wild-Type TDP-43 Transgenic MiceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.