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Chronic MIGRAINE as an emergent Systems Failure: Integrating Upstream Neuroimmunology, Gut–Brain Dysregulation, and Computational Chronification

2026-05-19

Abstract excerpt

Chronic migraine affects 1–2% of the global population and is the leading cause of neurological disability among women under 50 years of age. The advent of calcitonin gene–related peptide (CGRP)-targeting monoclonal antibodies and small-molecule receptor antagonists has constituted the first disease-specific preventive paradigm; nonetheless, real-world registries demonstrate that 30–50% of treated patients fail to...

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Literature Corpus work
65058ac8-d94c-5322-9c3e-b802ecda3dcb
DOI
10.20944/preprints202605.1223.v1
Open publication

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Chronic MIGRAINE as an emergent Systems Failure: Integrating Upstream Neuroimmunology, Gut–Brain Dysregulation, and Computational ChronificationDOI 10.20944/preprints202605.1223.v1
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