Article

Pathogenesis and Preventive Pharmacotherapy of Migraine Aura: A Critical Review of Cortical Spreading Depolarization Mechanisms, Drug Repurposing Evidence, and the Emerging Therapeutic Pipeline

2026-05-12

Abstract excerpt

<h4>Objective: </h4> To synthesise the pathobiology of cortical spreading depolarization (CSD) and critically appraise current and emerging pharmacological strategies specifically targeting migraine aura prevention. <h4>Background:</h4> Migraine with aura affects 25–30% of patients, and the aura phenomenon remains a substantial unmet preventive need. Calcitonin gene-related peptide (CGRP) monoclonal antibodies do...

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Literature Corpus work: af38fbb3-f247-56e8-942e-58a52665bb4a
DOI: 10.20944/preprints202605.0767.v1

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