A phenome-wide association study reveals novel phenotypic determinants of migraine risk in the UK Biobank.

doi:10.1111/head.70079

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

A phenome-wide association study reveals novel phenotypic determinants of migraine risk in the UK Biobank.

Headache - 1 Jan 2026

Shi Changhe, Li Shuangjie, Liang Yuanyuan, Ma Dongrui, Hu Zhengwei, Wang Yunchao, Wang Zhiyun, Qi Shasha, Hao Xiaoyan, Li Mengjie, Zuo Chunyan, Hao Chenwei, Feng Yanmei, Sun Yuemeng, Wang Chen, Yang Ruwei, Yang De, Wang Yonggang, Mao Chengyuan, Sun Shilei

Abstract excerpt

OBJECTIVE: To identify genetic and phenotypic determinants of migraine susceptibility and progression using a large-scale, hypothesis-free approach. BACKGROUND: Migraine is a common neurological disorder with a substantial individual and societal burden. While risk factors are known, hypothesis-driven approaches may overlook contributors. METHODS: We analyzed data from 502,364 UK Biobank participants (aged 37-73...

Topics

Humans
Migraine Disorders
United Kingdom
Female
Adult
Middle Aged
Male
Phenotype
Aged
Biological Specimen Banks

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Risk Factors

Genetic Predisposition to Disease

Genome-Wide Association Study

Phenomics

UK Biobank

Genetic Risk Score

Source

Open in PubMed

Identifiers

PMID: 42267619
DOI: 10.1111/head.70079

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A phenome-wide association study reveals novel phenotypic determinants of migraine risk in the UK Biobank.PMID 42267619Read ↗

Genetics of migraine.Semantic proximity Read ↗

Migraine genetics: from genome-wide association studies to translational insights.Semantic proximity Read ↗

Migraine: disease characterisation, biomarkers, and precision medicineSemantic proximity Read ↗

Phenome-wide analysis highlights putative causal relationships between self-reported migraine and other complex traits.Semantic proximity Read ↗

Migraine genetics: Status and road forward.Semantic proximity Read ↗

A review of migraine genetics: gathering genomic and transcriptomic factors.Semantic proximity Read ↗

Multi-omics Mendelian randomization integrating GWAS, eQTL and pQTL data revealed GSTM4 as a potential drug target for migraine.Semantic proximity Read ↗

A Genome-Wide Association Study Finds Genetic Associations with Broadly-Defined Headache in UK Biobank (N=223,773).Semantic proximity Read ↗

Machine Diagnostics and Machine Phenotyping of Migraine: A HUNT Study.Semantic proximity Read ↗

Migraine genetics: current findings and future lines of research.Semantic proximity Read ↗

Genetics of migraine: complexity, implications, and potential clinical applicationsSemantic proximity Read ↗

Genome-wide association studies in migraine: current state and route to follow.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.